First, you must make sure your distro's QEMU is built with JACK support:
* On Debian, this is not the case until QEMU 6.1. This is currently only in unstableand bullseye-backports. In the meantime, You should enable backports if you can use [https://apt.quantum2.xyz/qemu-jack/ this repository]are using bullseye and upgrade if you are using something older.
Normally, you can run applications with PipeWire's JACK support by running it with <code>pw-jack</code>, but this is not possible when using libvirt. Instead, you need PipeWire to provide drop-in JACK support. To do this: